These tables present type distribution by age. Since type distribution varies by age, the model allows for intervention efficacy for four different age groups: <2 years, 2 to <5 years, 5 to <10 years and > 10 years. If age-specific data are not available, type distribution data should be entered the same for all age categories.

This table presents estimated annual incidence of Disease 1 by age, the case-fatality ratio (CFR) by age, the percent complication 1 and the percent cases with hearing impairment.

This table presents estimated annual incidence of pneumococcal Decease 2 by age, the case-fatality ratio (CFR) by age, the percent cases with Decease 2 sequelae and the GP consultation rate per 100,000, All cells with a blue border can be modified by the user.

This table presents the estimated hospitalization rate, case-fatality ratio, and GP consultation rate for all-cause Decease 3.

This table presents the estimated GP consultation rate per 100,000, the adjustment factor for total Decease 4 cases, the total number of myringotomy procedures per 100,000, the Decease 4 complications ratio and the cases of sequelae per 100,000.

This table presents population level statistics for the country selected on the Model Setting sheet: England & Wales, Scotland, or the UK as a whole. Population data are presented in thousands (per 1,000) by age group. As newer data become available, the user can update these estimates using the grey, user defined cells.

This table presents the clinical trial efficacy data against invasive pneumococcal disease (Disease 1) for each of the interventions: Intervention B, and Intervention C. Efficacy data for Disease 1 are based on type specific efficacy from clinical trials. Based on the number of doses specified the model calculates, in the columns to the right, a maximum effectiveness for each intervention per type.

In the cells with a blue border, the user can specify the efficacy of the different interventions on the GP visits and hospitalisations. Based on the number of doses specified on the model calculates, in the columns to the right, a maximum effectiveness for the different interventions for each regimen.

This table presents the efficacy data against acute otitis media (AOM) for each of the interventions: Intervention B and Intervention C. Efficacy data for Decease 4 are not available by type or by dose. Instead, efficacy is modeled as efficacy against Pathogen 1 intervention types and non-intervention types. Efficacy at reducing disease caused by non-typable H. influenzae (Pathogen 1) is also included in the estimate of reduction in episodes of Decease 4 , as measured by Decease 4 -related GP visits and myringotomy procedures.

The table presents direct medical costs per acute episode for children and adults. For modelling purposes cut-off age introduced to discriminate between children and adults

The table presents yearly costs for treatment of long term complications

The table presents utility values not associated with disease.

This table displays disutility values for each disease outcome including short-term disutilities associated with acute episodes of disease and long-term disutilities that are assumed to persist over the individual's remaining lifetime. The short-term disutility values are disutility values per episode and are applied to the total number of cases of each disease in the current year (not discounted).

The long-term disutility values are disutility values per year and are applied to the total number of cases of sequelae in the current year and discounted each year for an individual's remaining lifetime.

This table presents age-specific average annual salaries and employment rates based on data from the Office of National Statistics and the Labour Force Survey. These two values are used to calculate the expected annual earnings by age group, which is used by the model to estimate the cost of productivity loss due to time lost from work due to pneumococcal-related illness. The user should use the cells with a blue border to update the annual salary estimates and employment rates in the UK.

This table presents estimates of time lost from work for patients of working age or time lost from work for working parents of sick children for each of the disease outcomes. These time estimates are multiplied by the estimated annual earnings for a parent to estimate productivity losses due to illness. As a default, time lost from work for parents of sick children is assumed to be equal to time lost from work for patients.. The cut off age for children to adults is defined on the worksheet "Costs". The user should go to this worksheet to modify the cut off age.